Biomedical Imaging and Visualization Model of Mitochondrial Dysfunction and Oxidative Stress in Alzheimer Disease

Abstract:

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Mitochondrial dysfunction and oxidative stress are among the earliest events linked to Alzheimer Disease and might play a causative role in disease onset and progression. In this paper, a biomedical imaging and visualization model was set to investigate the mitochondrial dysfunction and oxidative stress in Aβ/Cu2+-treated cells, which contribute in a significant manner to bioenergetic failure and mitochondrial dysfunction, by measuring mitochondrial membrane potential, Ca2+, chromatin condensation and ROS. This evaluating method opens a window for analyzing the protective effect of a certain substance in improving mitochondrial function and preventing oxidative stress in AD development.

Info:

Periodical:

Edited by:

Honghua Tan

Pages:

1179-1182

DOI:

10.4028/www.scientific.net/AMM.138-139.1179

Citation:

C. J. Lin et al., "Biomedical Imaging and Visualization Model of Mitochondrial Dysfunction and Oxidative Stress in Alzheimer Disease", Applied Mechanics and Materials, Vols. 138-139, pp. 1179-1182, 2012

Online since:

November 2011

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Price:

$35.00

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