Advances on the Pharmacology Research of Active Component in Humic Acid
The humic acids in young coal are complex compounds of aromatic-fatty group organic acid with content of functional groups like carboxy, phenolic hydroxyl group, benzoquinonyl, alcohol group , ketone group etc. The pharmacology research of humic acid advanced in slow progress as a result of composition complexity and raw material multiplicity. At first it was analysed that terpene, steroids and other bioactive substances existed in natural humic having effects on antibacterial, antiviral, antitumor and microcirculation improvement. A new way of molecular weight determination for fulvic acid was established by modification of cryoscopic constant which was proved by the detection of capillary electrophoresis and LC-MS then. In terms of Fulvic acid which molecular weight of 300-500, pharmacology of humic acid （FA/HA）- pyrones, humic acid (FA)- catechin, humic acid (FA)-saccharide metabolism of insulin, humic acid (FA)-allantoin-glycoconjugates,humic acid (FA)-glycyron-glycoconjugates which are prepared through selective degradation and branching modification were illustrated with similar pharmacophore (functional group) of Terpenoids, steroids by MTT experiment and flow cytometer.
X. P. Zhou et al., "Advances on the Pharmacology Research of Active Component in Humic Acid", Applied Mechanics and Materials, Vols. 138-139, pp. 1221-1227, 2012