Humic acids are biological macromolecules. It has been 500 years since “WU-JIN-SAN” (i.e. humic acid) reported in Compendium of Materia Medica. In recent 30 years tens of medical companies and institutions have done regular clinical trials, toxicological and harmacological research on bio-humic acids. Besides, German, Polish, Swiss, Finland et al. have also done similar research, with the similar efficacy of Chinese herbal medicine like “Streagthening Vital Qi's Capacity to Resist Pathogens”, “Readjusting Yin and Yang”, “remedy defects and rectify errors” which build a scientific fundament for medical application of bio-humic acid. Although bio-humic acids was relatively weak in pharmacological studies, it was still traceable. As a drug, how to make a prescription in the pharmacopoeia? This is the key issues which affect the progress in humic medical research. The author consider: First, the use of low-carbon biodegradation reduces the complexity of bio-humic acid molecules,then acoording to the active component by bio-humic acid, Pharmacological-pharmacodynamic, and determining the scope of medical applications could gradually overcome the bottleneck of medical research in bio-humic acid, accelerat the progress of medical research of bio-humic acid.