Modeling and Simulation of Pharmaceutical Powder Compaction
The finite element method was conducted to simulate the pharmaceutical powder compression process by using Drucker–Prager Cap model and elastic-plastic deformation theory. The effects of different friction coefficient on tablet property were systematically studied. The results show that the pressure-density curves shift towards right-hand side with slight decrease at smaller friction coefficient. The fluidity of powder remains the inverse decrease with the friction coefficient, and the density distribution changed more uniform. The maximum Mises stress becomes larger with the friction coefficient increased. The powder displacement decreases near die as the friction coefficient increasing. The research can both predict the tablet property and provide the theory reference for tablet practice production through the finite element analysis of pharmaceutical powder compaction.
Xianghua Liu, Zhenhua Bai, Yuanhua Shuang, Cunlong Zhou and Jian Shao
G. N. Si and C. Lan, "Modeling and Simulation of Pharmaceutical Powder Compaction", Applied Mechanics and Materials, Vols. 217-219, pp. 1403-1406, 2012