Micro-Macro Modeling for Systems Biology with MR-DEVS


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System-level understanding, which provides specific views on the system of interest focusing both on a macro and on a micro view, has been a recurrent theme in systems biology modeling. However only little work has been done to directly support the micro-macro linking explicitly in a modeling formalism. Multi-resolution discrete event systems specification (MR-DEVS) was introduced to model biology at system-level. MR-DEVS can model upward and downward causation and adapt to represent those systems with emergence and controlling relationship between the micro level and macro level in a biological system. Moreover, MR-DEVS is closed under coupling. And so, it can also model biological process at multiply level hierarchically and modularly.



Edited by:

Zhengyi Jiang, Yugui Li, Xiaoping Zhang, Jianmei Wang and Wenquan Sun




J. Gao et al., "Micro-Macro Modeling for Systems Biology with MR-DEVS", Applied Mechanics and Materials, Vols. 220-223, pp. 2975-2982, 2012

Online since:

November 2012




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