Micro-Macro Modeling for Systems Biology with MR-DEVS
System-level understanding, which provides specific views on the system of interest focusing both on a macro and on a micro view, has been a recurrent theme in systems biology modeling. However only little work has been done to directly support the micro-macro linking explicitly in a modeling formalism. Multi-resolution discrete event systems specification (MR-DEVS) was introduced to model biology at system-level. MR-DEVS can model upward and downward causation and adapt to represent those systems with emergence and controlling relationship between the micro level and macro level in a biological system. Moreover, MR-DEVS is closed under coupling. And so, it can also model biological process at multiply level hierarchically and modularly.
Zhengyi Jiang, Yugui Li, Xiaoping Zhang, Jianmei Wang and Wenquan Sun
J. Gao et al., "Micro-Macro Modeling for Systems Biology with MR-DEVS", Applied Mechanics and Materials, Vols. 220-223, pp. 2975-2982, 2012