Biorecognition on the Surface of Patterned Silicon/Silica and Gold/Silica Slide
As the substrates of biosensor or biomicroarray, silicon, silica and gold matrixes are usually used as the surfaces of bio-recognition. In this research, designed micro-patterned silicon/silica slide and gold/silica slide were utilized respectively as the substrates of DNA and protein detection. The results suggested the detection limit of protein and DNA on silicon/silica slide were 10 μg/L and 10 pM respectively, and those on gold/silica slide were 10 μg/L and 100 pM respectively. The patterned silicon/silica and gold/silica slide could be used as the support of bio-microarray in high-sensitive biorecognition.
Zhengyi Jiang, Yugui Li, Xiaoping Zhang, Jianmei Wang and Wenquan Sun
L. B. Nie et al., "Biorecognition on the Surface of Patterned Silicon/Silica and Gold/Silica Slide", Applied Mechanics and Materials, Vols. 220-223, pp. 2991-2995, 2012