LRB base isolation technology is different from the traditional continuous girder structure system, and shows good isolation performances. However, because fixed piers were canceled and all bearings were LRB, it is often considered that the reliability of structure might be reduced. Therefore, the reliability of LRB continuous girder bridges subject to seismic excitation was systematically studied from different indicators for the first time in this paper, the world's first double traffic double deck isolated continuous girder bridge – Dongjiang double-layer-pier isolated approach bridge in Dongguan of Guangdong province was adopted as study case. The results shows that, when the effect of pile-soil interaction is considered, LRB system still has a very good isolation performance; pounding subjected to seismic must be analyzed; dynamic stability needs checking when higher piers and larger earthquake displacement. Generally speaking, the reliability of LRB continuous girder bridges subject to seismic excitation won’t be reduced.