As the market competition became more fiercely and the customers’ needs of diversified products increased, small and medium enterprises (SME) were more and more aware of the importance of getting quick respond of the market. More and more enterprises felt the logistics cost pressure during this business. How to lower down the logistics cost especially the stock cost became crucial for these SME enterprises. Further more, for enterprises whose producing type is many varieties small batches, how to use valid method to decline inventory and waste, is a great hard nut to crack. This article targeted on inventory control of clothing manufacturing enterprises for research, RFID technology was applied in stock management, optimization method was adopted for inventory control based on RFID, optimization control model was built, and the route for declined inventory cost and waste was analyzed. Finally, the application method was verified according emulation.