A novel wood-based composite, Wood-PSt Composite, combining both advantages of wood and polymer was fabricated by impregnating styrene monomer into wood pores, followed by in-situ polymerization through a catalyst-thermal treatment inspired from the special porous structure. The manufacturing craft involving the impregnating craft and the polymerizing craft was studied and its structure was also observed by SEM. The analysis results indicated that the optimum impregnating condition was pressure: 0.5MPa, and time: 20min; and the monomer loading linearly correlated with pressure described as Y=201X+8.9, and linearly correlated with time described as Y=3.4X+31.4, respectively. The optimum polymerization craft was temperature: 80°C, time: 8h and AIBN: 3%. SEM observation showed that polystyrene generated in situ wood cellular structure and filled up wood pores under the optimum impregnating and polymerizing crafts, which was in accordance with the optimum manufacturing craft.