To resolve the problem of data transmitting in multi-sensor network possessing of a lot of sensors and processing sensors signals on the same time base and transmitting the results remotely, a three classes’ bus topology structure based on intelligent node was designed. The system comprised scene devices, transmission cable, and console. The scene devices included several gateways, more nodes and sensor groups. The console communicated remotely with gateways via Ethernet, and gateway communicated with nodes via CAN bus, each node managed a group of sensors via RS-485 bus. The designs of intelligent node were presented in detail including hardware design, transport protocols, as well as program flow. Above conceptual design was applied successfully in a certain multi-sensor network system principle prototype consisting of a console, a gateway and three nodes possessing of ten sensors. The results prove the conceptual design feasible.