Preparation of Henriol C Molecularly Imprinted Polymer Microspheres


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Molecular imprinted polymer micrcosheres (MIPMs) were prepared through precipitation polymerization by henriol C using as the template molecule. The morphologies of synthesized MIPMs were characterized by scanning electronmicroscope (SEM). Systematic investigations of the influences of key synthetic conditions, including functional monomers, cross-linkers and porogens, on the morphologies, yields and the recognition properties of the MIPs were conducted. The results indicated that the morphologies of MIPs with DVB as cross-linker was perfect, but their binding affinity is lower than that of MIPs with TRIM or EDMA as cross-linkers. And particle size of MIPs with TRIM as cross-linkers is small but with high binding affinity. Scatchard analysis revealed that the homogeneous binding sites were formed in the polymers. The application of MIPs with high affinity and excellent stereo-selectivity toward henriol C in solid-phase extraction (SPE) column might offer a novel method for the enrichment and determination of sesquiterpenoids in the traditional herbal medicine.



Edited by:

He Rui, Puneet Tandon and Teresa T. Zhang




Y. M. Luo et al., "Preparation of Henriol C Molecularly Imprinted Polymer Microspheres", Applied Mechanics and Materials, Vol. 664, pp. 34-37, 2014

Online since:

October 2014




[1] T.A. Sergeyeva, O.A. Slinchenko and L.A. Gorbach. Anal. Chim. Acta Vol. 659 1-2(2010), p.274.

[2] R J. Ansell. J. Chromatogr. B Vol. 804 (2004), p.151.

[3] N Kirsch, J Hedin-Dahlstrom and H Henschel. J Mol Catal B-Enzym Vol. 58 (2009), p.1725.

[4] JJ Ou, L Kong and C H Pan. J. Chromatogr. A Vol. 1117 (2006), p.163.

[5] J P Laia, X Yu Lub and C Y Lu. Anal. Chim. Acta Vol. 442 (2001), p.105.

[6] H Sambe, K Hoshina and J Haginaka. J. Chromatogr. A Vol. 1152 (2007), p.130.

[7] L Ye, R Weiss and K Mosbach. Macromolecules Vol. 33(2000), p.8239.

[8] C.J. Li, D.M. Zhang, Y. M. Luo: Phytochemistry. Vol. 69(2008), p.2867.

[9] R. Kiełczyński, M. Bryjak. Sep Purif Technol Vol. 41 (2005), p.231.

[10] X L Song, J H Li and J T Wang. Talanta Vol. 80 (2009), p.694.

[11] B Claude, P Morin and M Lafosse. Anal. Talanta Vol. 75 (2008), p.344.

[12] X Y Yin, Y Q Zhong and Y F Jiang. Spectrosc Spect Anal. Vol. 30(2010), p.2211.