Lead rubber bearings (LRB) is a new type of earthquake-resistance rubber bearings, formed by inserting lead-core into ordinary laminated rubber bearings, vertical supporting, horizontal displacement and hysteretic damping are hung in single unit together. Because lead-core can dissipate seismic energy and increase stiffness under load simultaneously, most of the requirements of the Seismic isolation system can be satisfied , the material-device has been found widespread application prospect in bridge Engineering. Equivalent linear model of hysteretic characteristics, computational method and the varying range of design parameters of LRB are presented. A full-bridge model of multi-span simple supported bridge with LRB is established in which box beam、LRB and piers are taken into account as a whole. By changing the property of earthquake excitation, ground motion intensity, vehicle speed and so on, the response of Bridge vibration system are analyzed, response law and characteristics of Bridge with LRB under different excitations are investigated systematically, compared with bridge with common bearings.