Investment casting method can fabricate the impeller slots with non-uniform thickness and distorted surface. The process of investment casting can be simulated by employing ProCAST software. The mesh of the casting was introduced in the article. The influence about the initial temperature of shell on the defects of the casting and the pouring temperature and the pouring speed on the effective stress of the casting was studied in this article. When the initial temperature of shell was 400°C,there was no defect in the casting. The pouring temperature of the casting, will produce a very strong influence on the effective stress. When the pouring temperature in this article was 800°C, the maximum effective stress of the casting was 108MPa.