Electrospun PLGA/SF Modified with Electrosprayed Microparticles: A Novel Biomimetic Composite Scaffold for Vascular Tissue Engineering
Here, a novel biomimetic scaffold with controlled diameters and mechanical properties was prepared from negatively charged silk fiber (SF) and poly (lactide-co-glycolide) (PLGA) by electrospinning technique. The fiber diameters and mechanical properties of the scaffolds were controlled by varying the weight ratio of PLGA/SF. Furthermore, in order to promote endothelialization on the scaffolds, pEGFP-ZNF580 loaded microparticles (MPs) were used to modify the surface of the electrospun scaffolds via electrospraying technique. Results showed that the composite scaffolds with these MPs could promote proliferation and migration of EA.hy926 cells significantly.
Z.S. Liu, L.P. Xu, X.D. Liang, Z.H. Wang and H.M. Zhang
L. Yu et al., "Electrospun PLGA/SF Modified with Electrosprayed Microparticles: A Novel Biomimetic Composite Scaffold for Vascular Tissue Engineering", Advanced Materials Research, Vol. 1015, pp. 336-339, 2014