Synthesis of One Novel Thieno[2,3-D]Pyrimidine Derivative Bearing a Sulfonylurea Moiety


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A novel thieno [2,3-d] pyrimidine compound (1) bearing a sulfonylurea moiety was synthesized from methyl 2-aminothiophene-3-carboxylate (2) through five steps including cyclization, chlorination, substitution with morpholine and piperazine, amidation and its structure was confirmed by 1H NMR and MS spectrum. The total yield of the five steps was 16.2% ( calculated from methyl 2-aminothiophene-3-carboxylate).



Edited by:

Z.S. Liu, L.P. Xu, X.D. Liang, Z.H. Wang and H.M. Zhang




C. Chen et al., "Synthesis of One Novel Thieno[2,3-D]Pyrimidine Derivative Bearing a Sulfonylurea Moiety", Advanced Materials Research, Vol. 1015, pp. 577-580, 2014

Online since:

August 2014




* - Corresponding Author

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