Cytotoxicity of pH-Responsive Dextrin Nanogels against Human Osteosarcoma 143B Cells
To overcome major side-effects, that is, cardiotoxicity of doxorubicin (DOX), pH-responsive dextrin nanogels (DNGs) were developed for using as a smart drug carrier. DOX-loaded DNGs were fabricated by emulsion cross-linking technique using glyoxal as a cross-linking agent to form acid-sensitive, acetal bonds. The objective of this study was to investigate the cytotoxicity of DOX-loaded DNGs on the human osteosarcoma 143B cell line. The cytotoxicity assay results showed that DOX-loaded DNGs retained high cell inhibition efficiency in 143B cells in a concentration- and treatment time-dependent manner. The cytotoxicity decreased with increasing ratio of glyoxal to dextrin. Observation of 143B cells by light microscopy showed the morphological changes after treatment with DOX-loaded DNGs. These results suggested that DOX-loaded DNGs with pH-sensitive properties is promising for use as a drug delivery system for cancer therapy.
Pornsak Sriamornsak, Sontaya Limmatvapirat and Suchada Piriyaprasart
S. Manchun et al., "Cytotoxicity of pH-Responsive Dextrin Nanogels against Human Osteosarcoma 143B Cells", Advanced Materials Research, Vol. 1060, pp. 227-230, 2015