Apatite-Coated Poly(lactic acid) Composites with Cell-Compatibility Prepared by a Biomimetic Method


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A new type of poly(lactic acid) (PLA)/calcium carbonates hybrid membrane incorporated with silicon, which is suggested to stimulate the formation of bones, was prepared using aminopropyltriethoxysilane (APTES) for bone repair materials. Carboxyl groups in PLA made a chemical bond with amino groups in APTES, resulting in the formation of the hybrid membrane. The membrane formed hydroxycarbonate apatite (HCA) on its surface after 3 days of soaking in simulated body fluid (SBF). X-ray energy dispersive spectroscopy showed the HCA layer includes Si with Ca and P. A result of osteoblast-like cellular proliferation on the substrates that the membrane coated with silicon-containing HCA had much higher cell-proliferation ability than the membrane.



Advanced Materials Research (Volumes 11-12)

Main Theme:

Edited by:

Masayuki Nogami, Riguang Jin, Toshihiro Kasuga and Wantai Yang




H. Maeda and T. Kasuga, "Apatite-Coated Poly(lactic acid) Composites with Cell-Compatibility Prepared by a Biomimetic Method", Advanced Materials Research, Vols. 11-12, pp. 239-242, 2006

Online since:

February 2006




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