The paper describes the methodology proposed in the PERPETUATE Project (funded by the Seventh Framework Programme – Theme ENV.2009.3.2.1.1). The methodology proposed in PERPETUATE uses a displacement-based approach for the vulnerability evaluation and design of interventions. The use of safety verification in terms of displacement, rather than strength, orients to new strengthening techniques and helps in the comprehension of interaction between structural elements and unmovable artistic assets. The procedure is based on the following fundamental steps: definition of performance limit states, specific for the cultural heritage assets (considering both structural and artistic assets); evaluation of seismic hazard and soil-foundation interactions; construction knowledge (non-destructive testing, material parameters, structural identification); development of structural models for the seismic analysis of masonry structures and artistic assets and design of interventions; application and validation of the methodology to case studies. Two main scales are considered: the seismic risk assessment at territorial scale and at the scale of single historic building or artistic assets. The final aim of the project is to develop European Guidelines for evaluation and mitigation of seismic risk to cultural heritage assets.