Thermal deformation flow stress equation of 1Cr12Ni3Mo2VNbN in the temperature range of 980 °C~1180 °C is established by means of hot simulation test and the regression analysis. The results show that the data obtained accords with hyperbolic sine function and the equation will also enrich the material performance database. The established equation is used in the blade forging production based on numerical simulation technology, and the numerical simulation results show that utilizing flat head billet can solve the problem of filling dissatisfaction at the root of the blade. Adopting water-based graphite lubricant provides better lubrication condition for blade forging. The equipment wear and energy consumption can be reduced by applying initial forging temperature of 1130°C in the blade forging process. The application of thermal deformation flow stress equation and numerical simulation technology can reduce the number of trial production, shorten the process design cycle and improve production efficiency in a large extent.