As tailor-welded blank having two or more sheet metal welded together, with different mechanical properties, coating and thicknesses, its yield strength and tensile strength are higher, but hardening exponent and elongation are lower than a single sheet. The different mechanical properties of substrates and weld movement have significant effects on TWB’s formability, different materials or thicknesses easily lead to uneven deformation and forming defects such as cracking, wrinkle and springback. This paper takes tailor-welded box-shaped part for example; the forming process and weld movement were simulated and analyzed. In this process, the weld type was ignored, only considering the weld-line position, using segmented blank holder to control the size of the blank holder force on both sides respectively. Three cases of sheet metal matching were carried out including: different thicknesses with same material, same thickness with different materials, and different thicknesses with different materials. Finally, some meaningful results were obtained.