The Study of Specificities of Interaction between Peptides and MHC Molecules

Abstract:

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Determining which peptides bind to a specific major histocompatibility complex (MHC) class I molecule is not only helpful to understand the mechanism of immunity, but also to develop effective anti-tumor epitope vaccines. In order to further study the specificity of MHC class I molecule binding antigen peptide, the support vector regression (SVR) and four amino acid descriptors were used to build four models of predicting binding affinities between peptides and MHC class I molecules. Comparison among performances of the four models indicated that the model based on physicochemical properties of amino acids is more satisfying (AC=75.0%, CC=0.499). Furthermore, the specificities of MHC class I molecule binding antigen peptide were obtained through analysis based on the contribution of the amino acids to peptide-MHC class I molecule binding affinities in the predictive model.

Info:

Periodical:

Advanced Materials Research (Volumes 143-144)

Edited by:

H. Wang, B.J. Zhang, X.Z. Liu, D.Z. Luo, S.B. Zhong

Pages:

1254-1258

DOI:

10.4028/www.scientific.net/AMR.143-144.1254

Citation:

T. Liu et al., "The Study of Specificities of Interaction between Peptides and MHC Molecules", Advanced Materials Research, Vols. 143-144, pp. 1254-1258, 2011

Online since:

October 2010

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Price:

$35.00

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