Poly(glycolic acid) (PGA) fibers produced by melt-spinning technology with different parameters may possess different structures, which may lead to different degradation behavior. In this paper, PGA fibers produced by different technology parameters were placed in phosphate buffer solution (PBS) (pH=7.4) at 37 °C up to 2 weeks to investigate the effect of melt-spinning technology on the degradation in vitro. Changes in weight loss and tensile strength of PGA fibers during degradation were investigated. The results showed that drawing multiple, drawing temperature and inherent viscosity of polymer had the influence on the performance of PGA fiber during degradation. The changes in weight loss and tensile strength during degradation in vitro indicated that the PGA fiber produced with higher drawing multiple degraded more slowly. The PGA fiber produced on higher drawing temperature degraded faster. The PGA fiber made from higher inherent viscosity polymer degraded more slowly.