With the extensive use of composite materials in aviation industry, the research of holes which affect composite residual strength has become very important. Based on MSC.Nastran, the stress of each laminate unit was calculated. Failure factor of composite laminates containing holes were calculated with the Tsai-Wu failure criterion. In this paper, the influence of hole shape and size on the composite laminate failure factor under compressive loading was studied. The relationship of hole shape, size and residual strength of composite laminates was briefly discussed. The results show that, under compressive loading, the stress concentration appears near the hole, there is a proportional relationship between the failure factor and hole size, the hole size and residual strength is the inverse relation.