Owing to the outstanding advantages of unbonded prestressed technology, it has been widely used in high-rise building floor. However, with the continuous improvement of the function requirements of the building, the boards with openings become more and more common, not only in new constructions but also in renovation projects. These holes will change the mechanical properties of the original floor, and cause stress concentration around the holes easily. This article carries on the simulation analysis by modeling the experimental model using ANSYS software, focuses on the deflection, crack and ultimate load of unbonded post-tensioned prestressed concrete board with open-hole (under uniform load in tensioning and loading stage). After making the comparative analyses to the mechanical behavior and failure mechanism under the different locations of the holes, the simulation results are compared with experimental results, shows that ANSYS can simulate the whole process of loading better, provides theoretical basis for its application and promotion in practical engineering.