A New Type of Colored Alumina/Glass Composite Biological Safety Assessment – Cell Toxicity and Hemolysis Tests
Objective: to evaluate the biological safety of a colored alumina/glass composite in terms of cytotoxicity and hemolytic ability. Methods: the cytotoxicity of an alumina/glass composite was evaluated with molecular filtration method. Cytotoxicity by spectrophotometric responses of test material and responses of a fresh rabbit red blood anticoagulant solution was determined by spectrophotometer. Results: cell-coated filter paper in contact with the test material showed the appearance of intracellular blue dye as the same staining density as in control samples, leading to a toxicity rating of 0. Colored alumina/glass composite assayed at <5% hemolysis. Conclusion: colored alumina/glass composite materials showed low cytotoxicity and non-acute hemolytic rates, representing overall good biological safety under these conditions.
Yiwang Bao, Li Tian and Jianghong Gong
B. Deng et al., "A New Type of Colored Alumina/Glass Composite Biological Safety Assessment – Cell Toxicity and Hemolysis Tests", Advanced Materials Research, Vol. 177, pp. 459-461, 2011