The key geometrical parameters of twist drills that had a great effect on the drilling performance of stainless steel were studied by Pro/E and DEFORM-3D softwares. The influence of chisel edge and tip angle of twist drill on the drilling force, torque and tool wear in the drilling process was researched, and meantime the effects were introduced by shortened the chisel edge length or adopted S-shape helical drill points as well. The tip angle of drill bit that affected the main cutting edge length, the cutting load on unit length, the proportion between cutting width and cutting thickness in the cutting lay, the cutting force, the torque, the chip formation and chip removal was introduced in detail. The choice of tip angle of twist drill was introduced. In drilling, it has important instructional significance for improvement of life of drill bit, advancement of productivity of drilling and processing quality of hole.