The mechanical response of airport pavement under multiple-gear of the new large aircraft loadings behaves differently from traditional mechanical response problems. In this paper, a 3-D finite element model of nine 5m×5m full size slabs rigid airport pavement with load transfer of joints and multilayer base system is established, using the finite element method. With the example of airplane A380, we analyzed the Von Mises stress distribution when the large aircraft loadings act on different locations of the pavement slabs. The result shows that the critical of Von Mises stress does not occur at the slab edge but closer to the center of the loading area in the edge load cases; in addition, through setting different parameters of joint load transfer stiffness, the relationship between the joints stiffness and the load transfer efficiency of adjacent slabs is found. It is demonstrated that for higher joint stiffness there is higher transfer efficiency.