In the article the organosilicon Quaternary Ammonium surfactant QAS222 was synthesized by one step reaction from silicane coupling agent and dodecyl amine, and its collecting ability to aluminosilicate minerals was investigated. The results showed that the percent conversion of dodecyl amine was more than 95% and the content of novel organosilicon in the production was about 96.53% when reaction was conducted at 80°C for 37 hours, with silicane coupling agent: N, N-Dimethyl dodecyl amine: KI=1.1:1:0.01 by the molar ratio, using anhydrous ethanol as solvent, protecting the reacting system with N2. The synthesizing technology was brief, efficient with low cost and easy to operate and industrialize. The flotation tests indicated that the organosilicon surfactant QAS222 was an effective collector for aluminosilicate minerals in whole pulp pH, by which the kaolinite, pyrophyllite and illite minerals could be floated well. It provided a good way for application preparation of organo-silicon compounds.