A Novel Synthesis of 3-Amino-1-Adamantanemethanol
3-amino-1-adamantanemethanol was synthesized from adamantane carboxylic acid following the procedures of Ritter reaction, hydrolysis, neutralization and reduced reaction without the participation of bromine. The total yield of 3-amino-1-adamantanemethanol was 43%. The structure of the target compound was characterized by elemental analysis, IR, MS, 1HNMR,etc. In addition, the possible reaction mechanisms was proposed.
Zhong Cao, Lixian Sun, Xueqiang Cao, Yinghe He
L. Cai et al., "A Novel Synthesis of 3-Amino-1-Adamantanemethanol", Advanced Materials Research, Vols. 233-235, pp. 225-228, 2011