Ordered Mesoporous SBA-15 for Controlled Release of Water-Insolube Drug
Ordered mesoporous SBA-15 was synthesized through hydrothermal process under acidic condition. The material was characterized by means of scanning electron microscopy (SEM), transmission electron microscopy (TEM), small-angle X-ray diffraction (SAXRD), and N2 adsorption-desorption. The results indicated that SBA-15 has 2-dimensional hexagonal p6mm mesoscopic structure and well-ordered parallel mesochannel. The as-obtained mesoporous silica was used for controlled release of water-insolube drug emodin. The loading capacity could achieve 6.64 mg/g, and the release profiles that studied in phosphate buffered saline (PBS, pH = 7.4) showed that released amount of emodin was 95.8 % after 48 h.
Zhong Cao, Yinghe He, Lixian Sun and Xueqiang Cao
J. J. Tao et al., "Ordered Mesoporous SBA-15 for Controlled Release of Water-Insolube Drug", Advanced Materials Research, Vols. 236-238, pp. 1873-1876, 2011