Preparation of Vitamin E Liposomes by the Thin Film Method and Study on its Leakage Rate


Article Preview

This text adopted the thin film method to prepare the vitamin E liposomes, the influence of proportion of components in vitamin E liposomes, and experiment condition on the envelopment rate were studied. The results showed that the optimum condition of the making technology of the vitamin E liposomes was:temperature42°C,m(vitamin E):m(lecithin)=1:25,m(vitamin E) :m(the cholesterol )=1:3, m(vitamin E) :m(the octadecylamine )=5:1, the phosphate buffer solution was 20 ml. In this case, the entrapment efficiency of the vitamin E liposomes was 76% .This method was accurate, and applicable for the preparation of vitamin E liposomes, and the property of it was very stable.



Advanced Materials Research (Volumes 236-238)

Edited by:

Zhong Cao, Yinghe He, Lixian Sun and Xueqiang Cao




W. G. Zhang et al., "Preparation of Vitamin E Liposomes by the Thin Film Method and Study on its Leakage Rate", Advanced Materials Research, Vols. 236-238, pp. 2207-2210, 2011

Online since:

May 2011




[1] Nianchu TANG, Aiyong QIU and Chuanlai XU: New-technology on Esterification Treatment of Soybean Oil Deodorized Distillate in Enzymatic Reaction. Food Science, 2007, 28(2): 142-144. In chinese.

[2] Xiaohong HU, Wentao LIU and Changwei LIU: Study on the Process of Extraction Vitamin E from Soybean Oil Deodorizer Distillate. China Oils and Fats, 2002, 27(2): 87. In chinese.

[3] Yang T, Choi MK and Cui FD: Preparation and evaluation of paclitaxel-loaded PEGylated immuno-liposome. J Control Release, 2007, 120(3): 169-177.

[4] EgbariaK, WeinerN: Liposomes as a topical drug delivery system. J Controlled release, 2003, 98(6): 47~50.

[5] Lu J, Jeon E and Lee BS: Targeted drug delivery crossing cytoplasmic membranes of intended cells via ligand-grafted sterically stabilized liposomes. J Control Release, 2006, 110(3): 505-513.


[6] Wu JM, Ren TQ: Preparation and characterization of encapsulated norcantharidin in liposomes. Chin Pharm J, 2005, 40(19): 1485-1489.

[7] Jingye Ma, Yun Xu and LinFu: Determination of vitamin E in human serum by RP HPLC. Chinese Journal of Health Laboratory Technology, 2006, 16(2): 95. In chinese.

Fetching data from Crossref.
This may take some time to load.