The Preparation of (E)-Resveratrol Nanoemulsion and In Vitro Release
Here a novel procedure to prepare stable (E)-resveratrol nanoemulsion is reported. The optimum (E)-resveratrol nanoemulsion formulation was sifted based on the pseudo ternary phase diagrams and particle size distribution. An optimized prescription was given as (E)-resveratrol 0.35%, EL-40 22.6%, 1,2-propylene glycol 5.03%, IPM 9.21% and water 62.81% (mass ratio), with the mean particle size 47.3 nm. The morphology of the (E)-resveratrol nanoemulsion was characterized by TEM. The test results demonstrate that the nanoemulsion could dramatically improve the stability and release of (E)-resveratrol.
Zhong Cao, Yinghe He, Lixian Sun and Xueqiang Cao
Y. Zhang et al., "The Preparation of (E)-Resveratrol Nanoemulsion and In Vitro Release", Advanced Materials Research, Vols. 236-238, pp. 2357-2361, 2011