Preparation, Characterization and Evaluation In Vitro of Naringenin-PVP K-30 Solid Dispersions

Abstract:

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Solid dispersions (SD) were prepared with naringenin and polyvinyl pyrrolidone k-30 (PVP k-30) by the solvent evaporation method with three drying methods (microwave-vacuum drying, MVD; and spray drying, SPD; vacuum drying, VD). The physical state was characterized by DSC, PXRD, SEM, and FT-IR. The results showed that the vitro dissolution rate and extent of naringenin was improved significantly by SD as compared with the pure drug and physical mixtures (PM). The results of FT-IR showed that naringenin is possibly interacted with PVP k-30 via intermolecular hydrogen bond, the results of DSC and PXRD showed that all of the SD prepared with three drying methods was completely amorphous. Compared with other drying methods, the MVD method can save time and energy. The physical state of SD prepared with the three drying methods that stored in the 40 °C/75% RH chamber was stable in three month. These results suggest that MVD is feasible to replace the traditional time-consuming and low efficiency drying procedure for preparation of SD.

Info:

Periodical:

Advanced Materials Research (Volumes 236-238)

Edited by:

Zhong Cao, Yinghe He, Lixian Sun and Xueqiang Cao

Pages:

2422-2428

DOI:

10.4028/www.scientific.net/AMR.236-238.2422

Citation:

S. J. Zhong et al., "Preparation, Characterization and Evaluation In Vitro of Naringenin-PVP K-30 Solid Dispersions", Advanced Materials Research, Vols. 236-238, pp. 2422-2428, 2011

Online since:

May 2011

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Price:

$35.00

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