Preparation and Characterization of Azithromycin-Loaded Nanostructured Lipid Carriers
To function lipophilic drug Azithromycin (AZM) as ophthalmic preparation, Azithromycin-loaded Nanostructured Lipid Carriers (AZM-NLC) were prepared by High Pressure Homogenization (HPH), and its stability was analyzed afterwards. Well-dissolved lipids of Azithromycin were selected, how the ratio of surfactants to lipids influenced the preparation of AZM-NLC was studied, and mature surfactant system was chosen. The optimized ratio of lipid carriers to emulsifiers [ polyoxyethylene (40) stearate - Poloxamer188 (7:3)] in this study was 1:6, and the final drug-capacity rate was 0.5%. Obtained by photon correlation spectroscopy, the mean particle size of AZM-NLC was 76±2 nm. The results showed that AZM-NLC had kept stable for 15 days, and mean particle size increased to 83 nm after four months.
Zhong Cao, Yinghe He, Lixian Sun and Xueqiang Cao
J. Y. Wu and Q. Xia, "Preparation and Characterization of Azithromycin-Loaded Nanostructured Lipid Carriers", Advanced Materials Research, Vols. 236-238, pp. 2917-2920, 2011