Preparation and Characterization of Azithromycin-Loaded Nanostructured Lipid Carriers

Abstract:

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To function lipophilic drug Azithromycin (AZM) as ophthalmic preparation, Azithromycin-loaded Nanostructured Lipid Carriers (AZM-NLC) were prepared by High Pressure Homogenization (HPH), and its stability was analyzed afterwards. Well-dissolved lipids of Azithromycin were selected, how the ratio of surfactants to lipids influenced the preparation of AZM-NLC was studied, and mature surfactant system was chosen. The optimized ratio of lipid carriers to emulsifiers [ polyoxyethylene (40) stearate - Poloxamer188 (7:3)] in this study was 1:6, and the final drug-capacity rate was 0.5%. Obtained by photon correlation spectroscopy, the mean particle size of AZM-NLC was 76±2 nm. The results showed that AZM-NLC had kept stable for 15 days, and mean particle size increased to 83 nm after four months.

Info:

Periodical:

Advanced Materials Research (Volumes 236-238)

Edited by:

Zhong Cao, Yinghe He, Lixian Sun and Xueqiang Cao

Pages:

2917-2920

DOI:

10.4028/www.scientific.net/AMR.236-238.2917

Citation:

J. Y. Wu and Q. Xia, "Preparation and Characterization of Azithromycin-Loaded Nanostructured Lipid Carriers", Advanced Materials Research, Vols. 236-238, pp. 2917-2920, 2011

Online since:

May 2011

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$35.00

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