Chiral Separation of Amino Acid Derivatives by Molecular Imprinting Technique
Molecularly imprinted polymers, based on the surface-modified silica gel, were prepared with silylanized silica gel as a carrier, acrylamide as functional monomer, ethylene dimethacrylate (EDMA) as crosslinker and Boc-L-phenylalanine as the template molecule. The results of HPLC shows that the imprinted polymers have good specific recognition of Boc-L-phenylalanine. The baseline separation of Boc-phenylalanine enantiomer was achieved in 20 min, the resolution was 1.84 and the maximum adsorption capacity was 6788 mg g-1.
Zhong Cao, Xueqiang Cao, Lixian Sun, Yinghe He
L. Q. Su et al., "Chiral Separation of Amino Acid Derivatives by Molecular Imprinting Technique", Advanced Materials Research, Vols. 239-242, pp. 2545-2548, 2011