Considering the effect of the actual landform and the pile-soil dynamical interaction, this paper uses the dynamic time interval analysis to analyze the response of horizontal seismic load of different segment lengths of high-piled wharfs. It makes research on the relative displacement, the acceleration, the maximum stress and the shear stress of the wharf construction and the variation of the shear force, the bending moment and the torque of the pile in the action of acceleration in true earthquake records. It determines the reasonable subdivision length of high-piled wharf in actual coast. Calculations show that, the wharf torsion caused by the asymmetry of terminal structure and pile, and the uneven stratum facilitates the response, and increases the shear stress of the pile. The placement of piles and the uneven stratum are the main factors of the internal force of terminal structure in action of earthquake, The optimal design of partial reinforcement should be adopted due to the considerable shear stress on the bezel panel. This method can provide reference to the design of the terminal structure in deep sea as well.