In the twenty-first century, with the development of technology, architecture is not just a shelter or even “a frozen music” (by Johann Wolfgang van Goethe). Instead, architecture becomes a huge communication channel between people and space. Thus with the integration of computational technology into architecture design, the new term—“smart space” has emerged. Some researchers have applied technology into intelligent space design, such as intelligent kitchen, smart collaboration design studio and smart health care environment. Sometimes creating a fancy or an alternative smart space is not enough, the essential factor of smart space is to satisfy human needs and keep good relationship between human and space. Therefore, this research will find out what the role of human-computer interaction in smart space design is. And the purpose of this research is to present two different cases of smart space: “Time home pub” and “BCI studio” and make the analysis of the transition from traditional architecture to smart space design. Also this research further discusses how HCI redefines the functions and lifestyle of traditional architecture.