A Simple Method for Quantification of Beta-Amyloid Using the Photo-Sensitive Thin Film Transistor

Abstract:

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This paper reports a technique for quantification of beta-amyloid protein by the use of photo sensitive thin film transistor (p-TFT). In recent studies, a beta-amyloid protein has strongly related a central role of the pathogenesis of Alzheimer’s disease (AD) and AD-related olfactory sensory loss. In the p-TFT, we observed the difference of the photo-current according to the presence of the particles with beta-amyloid, RAW 264.7 cells, and olfactory receptor neuron cells. The p-TFT shows the drain current reduction of about 50μA is caused by the RAW 264.7 cells with magnetic beads and beta-amyloid. Therefore, we suggest a new method of detecting small quantity of A-beta for early diagnosis of AD by using photo-sensitive thin film transistor (p-TFT) devices.

Info:

Periodical:

Edited by:

Lynn Khine and Julius M. Tsai

Pages:

58-61

DOI:

10.4028/www.scientific.net/AMR.254.58

Citation:

K. S. Kim et al., "A Simple Method for Quantification of Beta-Amyloid Using the Photo-Sensitive Thin Film Transistor", Advanced Materials Research, Vol. 254, pp. 58-61, 2011

Online since:

May 2011

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$35.00

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