Synthesis and Characterization of Polyesteramides Containing 5-Fluorouracil in the Main Chain
A series of polyesteramide containing 5-fluorouracil in the main chain were prepared by reacting potassium salt of 5-fluorouracil with N-(2-chloroacetoxylalkyl)-chloroacetamide.The copolymers were characterized by FT-IR, 1H-NMR, VPO and UV spectroscopy. The drug release profile in vitro of the copolymers were studied, the results showed prodrug could slow release 5-FU or 5-FU units in different solution, they may be likely to become potential antitumor prodrug.
Xiaoming Sang, Pengcheng Wang, Liqun Ai, Yungang Li and Jinglong Bu
J. Chang et al., "Synthesis and Characterization of Polyesteramides Containing 5-Fluorouracil in the Main Chain", Advanced Materials Research, Vols. 284-286, pp. 1728-1731, 2011