Synthesis and Characterization of Polyesteramides Containing 5-Fluorouracil in the Main Chain

Abstract:

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A series of polyesteramide containing 5-fluorouracil in the main chain were prepared by reacting potassium salt of 5-fluorouracil with N-(2-chloroacetoxylalkyl)-chloroacetamide.The copolymers were characterized by FT-IR, 1H-NMR, VPO and UV spectroscopy. The drug release profile in vitro of the copolymers were studied, the results showed prodrug could slow release 5-FU or 5-FU units in different solution, they may be likely to become potential antitumor prodrug.

Info:

Periodical:

Advanced Materials Research (Volumes 284-286)

Main Theme:

Edited by:

Xiaoming Sang, Pengcheng Wang, Liqun Ai, Yungang Li and Jinglong Bu

Pages:

1728-1731

DOI:

10.4028/www.scientific.net/AMR.284-286.1728

Citation:

J. Chang et al., "Synthesis and Characterization of Polyesteramides Containing 5-Fluorouracil in the Main Chain", Advanced Materials Research, Vols. 284-286, pp. 1728-1731, 2011

Online since:

July 2011

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$35.00

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