A theoretical study has been made on the cam-clamping device. In this article, we consider specifically the calculations of cam geometry, calculations of clamping force and clamping torque, conditions for self-locking, and conditions for contact strength. Machine fixtures are essential in the process of mechanical manufacturing. There are many different types of fixtures, such as manual jig, pneumatic clamps, hydraulic fixtures, electric fixtures, etc. There are also many ways of clamping, such as incline clamp, screw clamp, eccentric circle clamp, hinge clamp , among which the eccentric circle clamp finds wide applications, especially in fast-clamping devices. Although the circular eccentric fixture possesses the advantages of simple structure, convenient manufacturing, and low cost, it suffers the drawbacks of small clamping force, short clamping-surface travel distance, and unreliable self-locking mechanism. The cam-clamping device discussesed in this article involves replaceing the eccentric circle with a cam, as shown in Fig. 1. The cam profile curve can be designed according to any requirements. The advantages of this replacement are obvious, in addition to preserving the advantages of the circular eccentric fixture, the cam-clamping can be designed according to the actual needs of clamping paths and selection of the appropriate cam profile to improve the self-locking.