The long-retention of antibiotics in Calcium Phosphate Cement (CPC) may induce the development of drug resistance. Fast-releasing CPC containing antibiotics (FRCPC) was proposed as a solution to this problem and studied in this work. The FRCPC containing different proportions of soluble component were prepared and characterized. The setting time, compressive strength, degree of the conversion, in vitro antibiotic release and fracture surface morphology of FRCPC were studied. The results showed that the setting time increased, the compressive strength decreased, the in vitro antibiotic release accelerated with increasing fraction of soluble component in FRCPC. The setting time and compressive strength of FRCPC containing 20 wt% soluble components were close to the requirements of clinical applications, and the in vitro release was completed within 7 d. These results mentioned above showed that the FRCPC with suitable proportions of soluble components may prevent the development of drug resistance and may find applications in clinics.