A kind of novel polytetrafluoroethylene (PTFE)-based composite filled with nano SiO2 are developed for sliding tribological applications. The specimens are fabricated with the compression moulding technique. And the mechanical and tribological properties of the composites are investigated. It is demonstrated that these properties are influenced by the content of fillers. The wear resistances of all the developed PTFE composites are much higher than that of pure PTFE with very low coefficients of friction. Among the developed composites, the mixture of PTFE + 30% nano SiO2 exhibits the best combination of properties. The improved tribological performance of nano-SiO2 filled PTFE composites can be attributed to the improved structural integrity of the composites.