Preparation and Application of a Stable Biomembrane Mimetic Coating

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Two kinds of biomembrane mimetic polymers P(MPC-co-SMA) and P(MPC-SMA-TSMA) were synthesized with acrylate monomers 2-methacryloyloxyethyl phosphorylcholine (MPC), stearyl methacrylate (SMA) and 3-(methacryloyloxy) propyltrimethoxysilane (TSMA) by free radical copolymerization in solution with AIBN as initiator. The phosphorylcholine containing copolymers were dip-coated on cover glasses. The hydrophilicity, stability and surface structure of the coatings were measured by dynamic contact angles (DCA) in water. It was found that the coating surfaces were amphiphilic. The P(MPC-SMA-TSMA) coating was more stable than the P(MPC-co-SMA) one in aqueous environment due to crosslinking and grafting. The biocompatibility of the coatings was evaluated by platelet adhesion and protein adsorption. The copolymer P(MPC-SMA-TSMA) can be simply coated on a surface to fabricate a stable biomimetic coating with excellent hemocompatibility.

Info:

Periodical:

Advanced Materials Research (Volumes 311-313)

Edited by:

Zhongning Guo

Pages:

1630-1633

DOI:

10.4028/www.scientific.net/AMR.311-313.1630

Citation:

S. Yang et al., "Preparation and Application of a Stable Biomembrane Mimetic Coating", Advanced Materials Research, Vols. 311-313, pp. 1630-1633, 2011

Online since:

August 2011

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Price:

$35.00

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