Preparation and Characterization of Silver/Hydroxyapatite Nanoparticles
Aggregation problem limits the use of silver nanoparticles (nano-Ag). Liquid chemical reduction method was used to fabricate silver/hydroxyapatite nanoparticles (nano-Ag/HA) by depositing nano-Ag on the surface of hydroxyapatite nanoparticles (nano-HA). The XRD result shows nano-Ag/HA is a hybrid composite of hydroxyapatite and face-centered cubic crystalline silver. The TEM result confirms the size and distribution of nano-Ag are dependent on the mass ratio of deposited nano-Ag and nano-HA, decreasing the mass ratio can obtain nano-Ag with smaller size and less particle aggregation, which can be contributed to the heterogeneous nucleation effect of nano-HA on nano-Ag. Silver/hydroxyapatite/alginate composite dressing was fabricated by spraying nano-Ag/HA onto the surface of the alginate dressing. The test result of disc diffusion method shows the evident antimicrobial activity against Escherichia coli (E. coli) is assigned to nano-Ag/HA, no significant difference can be found between the dressings with 0.01g and 0.02g nano-Ag.
C. Guo et al., "Preparation and Characterization of Silver/Hydroxyapatite Nanoparticles", Advanced Materials Research, Vols. 311-313, pp. 1746-1750, 2011