The diversified market demand and shorter production cycle, as well as other factors, have increasingly complicate the problems of mold during design and manufacturing. Considering both design and manufacturing to facilitate the production progress, the effective collaborative development becomes an important issue for mold factor. The realization of DFM (Design for Manufacturing) is attached with more importance by the industry. More manufacturing-related data and information are added in the design phase, so that the manufacturing phase may be easier and smoother to enhance the competitive advantage, thus reducing the product development time and improving the production quality. Therefore, this research aimed to develop a web-based mold design for manufacturing architecture with knowledge management, and realize the application of DFM in the field of mold design/manufacturing with CAD redevelopment tool and by navigating design process. This research established a knowledge-based navigating process by utilizing design parameters and features, in order to increase the mold design/manufacturing efficiency to 50%, and avoid unnecessary human errors to ensure the accumulation and inheritance of correct knowledge.