Effects of Addition Amount, Particle Size Distribution and Average Particle Size of NaCl Porogen on the Pore Connectivity of Silk Fibroin (SF) /Hydroxyapatite (HA) Porous Composites


Article Preview

In order to investigate the effects of addition amount, particle size distribution and aver- age particle size of NaCl porogen on the pore connectivity of silk fibroin (SF) / hydroxyapatite (HA) porous composites. In this paper, the SF/HA composites were fabricated by means of isostatic pressing. The pore structure of SF/HA porous composites was observed by Scanning electron microscopy (SEM), and the air permeability was tested by home-made device. Results indicated that the larger addition amount of NaCl particles, the greater scope of NaCl particles size distribution and increased the average particle size of NaCl particles were able to make the pore connectivity of the material improved significantly. The materials with good pore connectivity, which were conducive to the immigration and adhesion of bone repair cells, information transmission and exchange with the outside tissue, and also benefit for bone tissue regeneration.



Advanced Materials Research (Volumes 332-334)

Edited by:

Xiaoming Qian and Huawu Liu




Z. R. Xia et al., "Effects of Addition Amount, Particle Size Distribution and Average Particle Size of NaCl Porogen on the Pore Connectivity of Silk Fibroin (SF) /Hydroxyapatite (HA) Porous Composites", Advanced Materials Research, Vols. 332-334, pp. 1904-1909, 2011

Online since:

September 2011




[1] A.S. Greenwald, S.D. Boden, V.M. Goldberg, Yusuf Khan, C.T. Laurencin and R.N. rosier: J Bone Joint Surg. Vol. 83A (2001), pp.98-103.

[2] F.C. Den Boer, B.W. Wippermann, T.J. Blokhuis, Peter Patka, F.C. Bakker and H.J.T.M. Haarman: J Orthopaed Res. Vol. 21(2003), pp.521-528.

[3] S.Q. Yan, C.X. Zhao, X.F. Wu, Q Zhang, M.Z. Li: Sci China Chem. Vol. 53(2010), pp.535-541.

[4] H. Yang, L Zhang, H Zhang and K.W. Xu: Fuhe Cailiao Xuebao. Vol. 24(2007), pp.141-146.

[5] S. Z Lu, M.Z. Li and L Bai: Silk Monthly. Vol. 2(2006), pp.17-23.

[6] Van Vlack and H. Lawrence: Elements of Materials Science and Engineering (4th ed. Reading, MA: Addison-Wesley, 1980).

[7] W.L. Murphy, R.G. Dennis, J.L. Kileny and D.J. Mooney: Tissue Eng. Vol. 8(2002), pp.43-52.

[8] J.C. Zhang, L.B. Wu, D.Y. Jing and J.D. Ding: Polymer. Vol. 46(2005), p.4979–4985.

[9] A. Uchida, Nade SML, E.R. McCartncy and W. Ching: J bone Joint Surg. Vol. 66B(1984), pp.269-275.

[10] E. White and E.C. Shors: Dent Clin North Amer. Vol. 30(1986), pp.49-67.

[11] J.J. Klawitter and S.F. Hulbert: J Biomed Mater Res Sym. Vol. 2(1971), pp.161-167.

[12] J. Kuhne, R. Bartl, B. Frish, C. Hammer, V. Jansson, M. Zimmer: Acta Orthop Scand. Vol. 65(1994), pp.246-252.

[13] B. Flautre, M. Descamps, C. Delecourt, M.C. Blary and P. Hardouin: J Mater Sci: Mater Med. Vol. 12(2001), pp.679-682.

DOI: https://doi.org/10.1023/a:1011256107282

[14] K. Shimazaki and V. Mooney: J Orthop Res. Vol. 3(1985), pp.301-310.