TiO2 nanotube arrays were fabricated by anodic oxidation in electrolytes containing F- in this paper. To achieve local drug delivery, anodized titanium with nanotube layer structures were loaded with ibuprofen(IBU) using a vacuum drying method in which drug molecules were tiled on the anodized titanium to dry in vacuum drying oven. The morphology and phase of TiO2 nanotube were characterized by means of FE-SEM, XRD, FIRT, respectively. Results indicated IBU were loaded on titania nanotube (220nm inner diameter and 7.3μm deep) layer successfully. But the IBU loading on anatase is more than on amorphism. And different phases with drug loading have the same release process, which was divided into quick release and stable release. Quick release processes about Anatase/IBU are fitted with different equations. We found that the experimental data fit the theoretical first-order curve the best. It suggested that the drug carrier had the properties of sustained release.