Computational Analysis of Microrna Profiles and their Target Genes Involved in Multidrug Resistance of Breast Cancer Cell
Multidrug resistance remains a major clinical obstacle to successful treatment of breast cancer and leads to poor prognosis for the patients. Recently studies have shown that microRNAs play an important role in breast cancer cell resistance to chemotherapeutic agents. In this study, microRNA expression profiles of MCF-7/AdrVp and MCF-7 were analyzed using microarray. Gene Ontology and pathways mapping tools were employed to analysis systemically the biological processes and signaling pathways affected by differential expression microRNAs. The results indicated that breast cancer cell resistant to chemotherapy was associated with a group of microRNAs. Gene Ontology and pathway mapping are valid and effective approach to analysis the function of microRNAs and the results could be a guideline for further investigation.
G. Q. Chen and Z. W. Zhao, "Computational Analysis of Microrna Profiles and their Target Genes Involved in Multidrug Resistance of Breast Cancer Cell", Advanced Materials Research, Vol. 345, pp. 304-309, 2012