In order to develop stamping well pump with high efficiency, 4SP14 stainless steel stamping well pump was set as an example. Combined with the features of stamping technology, this research was taken on raising the efficiency of stamping well pump, using hydraulic design of impeller and CFD and regression test method. The experiment was designed with four factors including impeller inlet angle Δβ1, impeller outlet angle β2, and impeller outlet width b2 and inlet width of guide vane B3. 30 groups of programs were designed according to CCD central composite test method. The whole flow field of well pump at the operating point was simulated by FLUENT using the standard k-ε model, SIMPLE algorithm, first-order upwind scheme. 30 group of efficiency were obtained. Use regression equation to fit the function relationship between the efficiency value and each factor. Through the analysis of the regression equation, the optimal combination of geometric parameters can be found as inlet angle 4º, outlet angle 27.5º, outlet width 9.5mm and inlet width of guide vane 11.5mm. After manufactured and tested according to the above geometric parameters, the efficiency of the optimal model pump reaches 60.28%, which reaches the international advanced level.