Electrochemiluminescence Determination of Pethidine by Capillary Electrophoresis Separation

Abstract:

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A sensitive determination method for pethidine based on capillary electrophoresis-electrochemiluminescence detection was described. Analysis conditions affecting separation and detection were discussed and optimized in detail. The mixture solution of 5 mmol/L Ru(bpy)32+ and 50 mmol/L phosphate buffer at pH 7.46 were added to the detection reservoir. End-column detection of pethidine was performed. Sensitive electrochemiluminescence detection was obtained at applied voltage of 1.20 V. A baseline separation of pethidine was achieved using a phosphate running buffer at pH 7.46 by electrokinetic injection for 10 s at 10 kV. A detection limit of 5.0×10-8 M (S/N=3) was achieved.

Info:

Periodical:

Advanced Materials Research (Volumes 361-363)

Edited by:

Qunjie Xu, Honghua Ge and Junxi Zhang

Pages:

1914-1917

DOI:

10.4028/www.scientific.net/AMR.361-363.1914

Citation:

Q. Xiang et al., "Electrochemiluminescence Determination of Pethidine by Capillary Electrophoresis Separation", Advanced Materials Research, Vols. 361-363, pp. 1914-1917, 2012

Online since:

October 2011

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Price:

$35.00

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